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BioEcOrganic Presentación: Ciencia para la Vida – El Libro, el Proyecto EHCP y una Revolución Ética en Salud Celular
Resumen sinóptico científico-divulgativo
En el contexto de la crisis sanitaria y ecológica global que atraviesa la humanidad, BioEcOrganic presenta una obra de referencia en la frontera entre la ciencia médica, la biología celular, la ética ecológica y la divulgación comprometida: un libro pionero que aborda el estrés oxidativo como eje patogénico central en la mayoría de enfermedades modernas, sustentado en fundamentos de la bioquímica celular, la fisiopatología sistémica, y teorías contemporáneas sobre los mecanismos moleculares del deterioro humano.
El libro articulará conocimientos generados por médicos, científicos e investigadores éticamente comprometidos, que buscan no solo comprender las raíces celulares del daño oxidativo, sino proponer hipótesis operativas, estrategias terapéuticas, y caminos de prevención accesibles a la sociedad civil, al tiempo que se vulgariza, en el mejor sentido ilustrado del término, la ciencia de la salud humana. Desde una visión holística e integradora, se plantea una profilaxis radical, centrada en un modelo dietético BioEcOrganic, libre de pesticidas, hormonas, metales pesados y otros contaminantes, acompañado por suplementación antioxidante natural de origen vegetal y mineral, todo bajo el sello ecológico BEO – BioEcOrganic, garantía ética de trazabilidad, sostenibilidad, y salud integral para el ser humano y su entorno.
Esta visión teórico-práctica se encarna en el Easy Healthy Cells Project (EHCP), una propuesta de investigación científica transdisciplinar que busca financiamiento privado, pero fundamentado en un capitalismo virtuoso, guiado por principios hipocráticos, moral humanista, y una ética deontológica que rescata el valor de la vida como bien supremo. Este proyecto invita a investigadores, médicos y ciudadanos de buena voluntad a colaborar en una transformación de los paradigmas actuales de la salud, desde lo microcelular hasta lo sistémico, defendiendo la dignidad de toda existencia humana en armonía con su biosfera.
Uno de los pilares aplicables de este esfuerzo es la BioTerapia, una fase práctica del EHCP que articula un enfoque terapéutico múltiple: dieta antioxidante bioecológica, suplementación segura, baños dermales fitoterapéuticos, y protocolos inyectables naturales no invasivos. Esta terapia está concebida como complementaria, nunca excluyente, pensada especialmente para ser aplicada en casos clínicos críticos —como niños con cáncer en Venezuela—, donde el sistema sanitario ha colapsado, pero la esperanza permanece en el amor, la ciencia y la innovación solidaria.
BioEcOrganic no es solo una marca, un libro o un proyecto. Es una propuesta epistemológica y moral para sanar al ser humano desde su célula hasta su civilización. Es un llamado a recuperar el sentido del cuidado, la responsabilidad intergeneracional y la armonía entre ciencia, naturaleza y cultura.
EHCP es salud, ciencia y alma en acción.
1. EHCP BOOK
Index
The document provides an index of topics including the emergence of life, oxidative stress (OS), and related diseases.
It lists various diseases possibly linked to OS affecting different body systems.
Popular Knowledge related to OS
The document discusses popular knowledge related to oxidative stress, such as fatigue and inflammation.
It also discusses methods to avoid and cope with OS, including BioEcOrganic diets and antioxidants.
It gives an overview of The #EasyHealthyCellsProject.
Resumed View of EHCP Research Proposal
This section simply states that a resumed view of the EHCP Research Proposal is provided.
Introduction: Our Hypotheses
The introduction posits that changing daily habits towards BioEcOrganic food, increasing antioxidant intake, improving breathing and hydration, and avoiding harmful substances can improve health.
The purpose is to encourage readers to adopt these approaches to avoid oxidative stress-induced illnesses.
How emerged Life in Paleo World
Life on Earth emerged 3.5 to 4 billion years ago.
The chemical evolution theory suggests life emerged from non-living matter through chemical reactions.
The Miller-Urey experiment demonstrated the formation of organic molecules under early Earth conditions.
Fossilized microorganisms
Stromatolites, dating back over 3 billion years, provide evidence of early life on Earth.
The theory of evolution explains how life on Earth has diversified and adapted over billions of years.
The study of life's origin in the Paleo World is an active area of research.
The Cell, a Brief History
The cell is the fundamental unit of life.
Cell theory states that all living organisms are composed of cells.
The endosymbiotic theory suggests eukaryotic cells evolved from symbiotic relationships between prokaryotic cells.
Biology
The study of cells is central to biology, with cells carrying out vital functions.
Cells are the basic units of evolution, with changes in DNA driving genetic variation.
The study of cells has transformed our understanding of life.
From Medicine Man and Herbalists to Physicians and Biologists
Medical practices have evolved significantly, transitioning from traditional healers to modern physicians and biologists.
The advancement of medicine is attributed to scientific knowledge, technological innovations, and the scientific method.
Scientific advancements in biology have deepened the understanding of disease mechanisms.
Non Organic new neighbors of precious cells: pesticides, electromagnetic, heavy metals, e.g
The presence of non-organic substances, such as pesticides, electromagnetic fields (EMFs), and heavy metals, can negatively impact cellular processes.
Studies have linked pesticide exposure to neurotoxicity, endocrine disruption, and cancer.
Heavy metals can disrupt cellular processes by binding to functional groups in proteins and enzymes.
Electromagnetic Fields (EMFs)
EMFs are generated by electrical and electronic devices, and some studies have reported associations between EMF exposure and increased risk of cancer.
Understanding the potential effects of EMFs on precious cells is essential to ensure the safety of human populations.
Oxidative Stress, O.S.
Oxidative stress is a physiological imbalance between the production of reactive oxygen species (ROS) and the body's antioxidant defense system, leading to cellular damage.
Oxidative stress profoundly affects cellular function and is associated with various diseases.
Preventing and managing oxidative stress is crucial for maintaining optimal health.
When and Where Oxidative Stress Occurs
Oxidative stress can occur due to environmental pollutants, smoking, alcohol, exercise, and chronic infections.
Oxidative stress is implicated in numerous diseases, including cardiovascular diseases, neurodegenerative disorders, and cancer.
Antioxidant-rich foods can help combat oxidative stress.
Discussion
Prolonged exposure to ROS can overwhelm the body's defense systems, leading to cellular damage.
Antioxidant supplementation, lifestyle modifications, and novel therapeutic approaches are being explored to mitigate oxidative stress.
Pollution as main OS enhancer
The discussion explores the hypothesis that pollution can be a main operating system (OS) enhancer, focusing on biological aspects.
Hormesis is a biological phenomenon where exposure to low doses of harmful agents can trigger adaptive responses.
Long-term exposure to high pollution levels can have severe health consequences for organisms.
Types of stresses and OS
A list of diseases, illnesses, and disorders that are linked to oxidative stress (OS) in various systems and organs of the body.
This includes conditions in the brain and nervous system, eye, skin, buccal apparatus, heart and circulatory system, bones, muscles, glands, kidney, liver, digestive system, lungs and respiratory system, and auditory system.
Brain and Nervous System
Diseases in the Brain and Nervous System linked to OS include Alzheimer's and Parkinson's.
Diseases in the eye linked to OS include macular degeneration, cataracts, and glaucoma.
Other areas include skin, oral health, heart, and bones.
Brain and Nervous System
The Brain and Nervous System is affected by conditions such as Alzheimer's, Parkinson's, Multiple sclerosis, and Epilepsy.
The Eye is affected by Glaucoma, Cataracts, and Age-related macular degeneration.
Various diseases are associated with other systems like the buccal apparatus, heart, kidneys and lymphatic system.
Popular Knowledges related to OS: fatigue, pain, cellulitis, inflamation, liquid retention
Oxidative stress contributes to fatigue, pain, inflammation, and fluid retention.
Oxidative stress can affect anyone and occur locally or systemically.
Oxidative stress plays a role in aging and age-related diseases.
Medicine and Health
Oxidative stress is a target for therapeutic interventions, including antioxidant therapies.
Cells possess antioxidant defense systems to maintain redox balance.
Mitochondria are susceptible to oxidative stress, with dysfunction linked to various diseases.
How to avoid OS: BioEcOrganic diets
A BioEcOrganic diet emphasizes organic, biodynamic, and ecologically grown foods.
It can be followed at any time to support health, especially by choosing organic produce and minimizing processed foods.
A balanced diet rich in antioxidants, along with physical activity and stress management, reduces oxidative stress.
How to cope with OS: Antioxidants, endogenous and exogenous
Coping with oxidative stress involves reducing ROS production and increasing antioxidant defenses.
Strategies include consuming a balanced diet, supplementing with antioxidants, staying hydrated, and exercising regularly.
It's important to minimize exposure to environmental toxins, limit alcohol consumption, and quit smoking.
Biotherapies, the proposed investigation to fund
The LEA Foundation Easy Healthy Cells Project aims to develop and promote innovative biotherapies.
These therapies use living organisms or their components to treat diseases.
Funding this project would support research, equipment, and clinical trials.
Extra Positive Behavior: better oxygenation and hydration of body cells
Behaviors promoting better oxygenation and hydration of body cells positively affect overall health.
Regular exercise and deep breathing exercises improve blood circulation and oxygen intake.
Maintaining good posture and managing stress promote better lung expansion and oxygenation.
The #EasyHealthyCellsProject overview
The #EasyHealthyCellsProject is an initiative aimed at promoting easy and healthy lifestyle habits to improve cellular health.
It focuses on raising awareness about the importance of maintaining healthy cells for overall well-being.
It emphasizes nutrition, physical activity, sleep, stress management, and avoiding toxins.
Online Resources
The project provides online resources to educate individuals about cellular health and guide them towards healthy habits.
By making small, sustainable changes in lifestyle choices, individuals can optimize their overall well-being and lead healthier lives.
An opportunity to get to know the cells that make up our bodies, of our loved ones.
A shift in lifestyle to eating without pesticides or heavy metals, avoiding dehydration, and adding excellent quality nutrients can improve health.
Modern diseases can be caused by chronic cellular damage from pesticides, heavy metals, and toxins from plastics.
The goal is to promote organic products and nutritional supplements to finance toxicology studies on pesticides and electromagnetic contamination.
Our hypothesis
The hypothesis is that destructive activity of pesticides could be enhanced by electromagnetic contamination affecting cell membranes.
An ecotoxicology study will use fish species to test the combined effects of pesticides and electromagnetic sources.
Antioxidants VS oxidative stress
Oxidative stress is caused by free radicals destroying cell membranes and enhancing probabilities of modern diseases.
The importance of taking care of every cell and promoting ecology and a healthy environment is emphasized.
Seeking support to fund ecotoxicology experiments with pesticides and electromagnetic pollution on fishes.
Lack of control of free radicals
Lack of control of free radicals, tiny molecules that destroy cell membranes and DNA, causes a chain reaction leading to various conditions.
Mention of heavy metals and arsenic in frozen fish.
Another cell imbalance begins
Another cell imbalance begins if there are not enough copies of genes to produce antioxidants.
Oxidative stress results from chemical and electromagnetic hazards coupled with various other stresses.
The hypothesis is that chemical and electromagnetic stress could be enhancing the flow of 'bad molecules' into cells.
Electromagnetism...#pollution...
Concerns are shared about WiFi networks in schools, glyphosate, and heart attacks related to air pollution.
The project proposes governments, universities, and NGOs to address the health and contamination issues.
Contamination and electromagnetic stress multi-factorially stresses cells and tissues.
Now our daughter studies in an educational center that is next to a mega radio and TV repeater antenna
Concerns about the impact of environmental contamination, including electromagnetic fields, on cells and tissues.
Proposal of an anatomical theory linking contamination to brain damage and various conditions.
Moins de cancers chez les consommateurs d’aliments bio
A study reveals a 25% reduction in cancer risk among regular consumers of organic food compared to less frequent consumers.
prestar atención
Intervention of Dr. Miguel Ángel Martínez González recommending attention to certain factors.
Combining the recommendations with organically sourced food may lead to longevity and health.
Protect your family...eat organic bio eco food mainly...add good nutrients
Recommendation to protect family by eating organic food and adding organic nutrients.
A code is provided to register as a guest and get the lowest price on nutrients from @BioEcOrganic origin.
Seeking support to carry out ecotoxicology research with fishes using pesticides and electromagnetic sources.
CELL ORIGINS AND METABOLISM
Vitamin C, also known as ascorbic acid, prevents scurvy.
Some animals, including humans, have lost the capability to produce it.
The gene that codes for gulonolactone oxidase is present in humans but is not active.
The Functions of Vitamin C
Vitamin C is essential for proper collagen folding.
It is a co-substrate for multiple enzymes involved in biosynthesis.
Vitamin C is one of the best physiological non-toxic antioxidants because it reacts with many different kinds of ROS.
Like humans, other animals unable to synthesize vitamin C can always find a supply of it in other organisms that synthesize it on their own, namely plants.
Since one of the products of the reaction catalysed by gulonolactone oxidase is hydrogen peroxide, Halliwell suggested in 2001 that the loss of biosynthesis balanced the "cost" of production.
There is a third yet still unexplored possibility
Organisms that have lost vitamin C biosynthesis have an advantage: they can finely regulate HIF1α activation on the basis of the dietary intake of vitamin C.
Pseudogenes are not inert, but can have a significant role in epigenetic control of gene expression.
Hi group! I am Prof. Mikel de Elguezabal Méndez, Biologist, Ph.D.
The speaker aims to help humankind through the Egura Project and the Easy Healthy Cells Project.
Recommends following @BioEcOrganic at Instagram for healthy cells and organs by eating organic food.
Hypotheses include the impact of cell membrane permeability, free radical production, and genes on cell health.
Hypotheses
There are three main hypotheses related to membrane permeability, free radical production, and the role of genes in cancer and autoimmune diseases.
Also talks about discovering binary codes in the Matrix, with a long and happy life possible and cheaper than medicines.
A book is being written and funds are being sought for an investigation in Navarre, Spain.
Proposal for a Pesticide Ecotoxicology and Electromagnetic Contamination Project (EPCE) + Physical-Biomedical Chemistry Genetic-Probabilistic (PFQBGP)
Outlines a project with two phases: ecotoxicology tests and modeling of contaminants in human organs.
The aim is to investigate the joint incidence of electromagnetic and chemical contamination on vertebrate models.
Discusses the dehydration effect of alcohol and recommends fermented beverages.
Remembering a Brief and Convenient Hypothesis: oxidative stress.
Modern health conditions can be understood from oxidative stress, caused by environmental factors and an imbalance of reactive species.
Research is focused on experimental ecotoxicology tests, mathematical modeling, and applied research based on antioxidant diets.
Lay summary
A study will be conducted to investigate the impact of electromagnetic fields on Oxidative Stress enhancement and to propose a new Biotherapy.
Proposes to carry out a triple phase study with ecotoxicology tests on fishes, mathematical modeling, and applied Biotherapy.
Study limitations and contingency plans
Cancer researchers have focused on treatments like radiotherapy, chemotherapy, and immunotherapy.
There should be more effort in the research on the causes triggering all types of cancer.
Explains that their proposal suggests that an integrated Translational approach can be constructed to tackle cancer spreading through new societies adopting industrial way of life.
Project aims and objectives
Phase 1 aims to understand the effects of electromagnetic fields on free radicals generation by measuring cell and organelles' membranes permeability that could increase the probabilities of chemical pollutants.
Phase 2 aims to set the probabilistic algorithms of the occurrence of OS for every cells types in the human organic systems for each chemical pollutant.
Phase 3 aims at avoiding the former concepts (free radicals/oxidative stress/ cell failure) with the help of the 'BioTherapy' designed for cancer patients.
The objective of Phase 3 is to measure the expected beneficial effects of the BioTherapy on the well being of cancer patients
The objective of Phase 3 is to measure the beneficial effects of the BioTherapy on cancer patients undergoing classical therapies.
The overall aim of the BioTherapy is to provide a harmless additional treatment to save more human lives.
A discussion of the expected scientific and social relevance in each phase.
Work plan and timeline
Phase 1 of EHCP would take 1 year round of various Ecotoxicology essays at contracted University labs.
Phase 2 and Phase 3 would be 3 years of continuous work in parallel.
Study limitations and contingency plans
For Phase 1, the main threat that could limitate the ecotoxicology study would be not to count with the diploid and triploid fries of Salmo trutta fario specimens, In such a case, we will use the Zebrafish model.
For Phase 2, the main threat possibly limiting this
For Phase 2, the main threat possibly limiting the research could be the lack of enough metadata to built the 2 robust matrices we are willing: pollutants & cells types nature.
For Phase 3 we only visionate an unique possible limitation during the quadruple treatment of the BioTherapy: a potential adverse reaction for any of the 4 treatments in at least 1 of the patients under study.
a discussion of the impact.
Scientificand social relevance
Impact of Phase 1: It would contribute as the first ecotoxicology essay putting together pesticides and electromagnetics sources together on vertebrate models.
Impact of Phase 2: The scientists and colleagues will have matrices and rethink in better ways to get successful models.
Impact of Phase 3: the BioTherapy approach it will be affordable in poor countries.
Ethical, social, legal and environmental project implications
Fishes will be used as vertebrate models and quadruples treatments will be applied to a given population of children with cancer.
Dissemination, social engagement and knowledge transfer
Reports will be made and papers will be published for each phase of the Project in accessible Scientific Journals.
All materials, videos and presentations will be able to share it with any researcher or professor or health professional willing to replicate the project's information and tools towards its own country or region in any language.
Mention of various referenced materials and authors.
Ladas, E. 2018. Integrative Medicine in Childhood Cancer. The Journal of
Continues listing cited references.
Matés, J. 2000. Effects of antioxidant enzymes in the molecular control of reactive
Continues listing cited references.
Consumables Comments: Supplements, treatments and organic food for Phase 3 at Pediatric Oncology Centre. Software for Phase 2
Continues listing budget information.
Project Team
Sure! Here's the translation into English:
EHCP Team:
Phase 1:
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Dr., Biologist, Ecologist, Oceanographer, Mikel de Elguezabal, and contracted laboratory: EHU (University of the Basque Country).
Phase 2:
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Dr. Gregorio Martínez, Chemist, Geochemist, Oceanographer (expert in heavy metals), UDO, Venezuela.
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Dr. Edgar Márquez, Chemist (expert in organic compounds and metabolites, structural chemical modeling), UNINORTE, Colombia.
Phase 3:
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Dr. Isabel Chaves Pinto, Pediatrician (specialized in child nutrition), UCV, Venezuela.
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Dr. Elizabeth Méndez Rodulfo, Ecologist (specialized in coastal environments), UDO, Venezuela.
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10 Chapters YouTube, soon...
bioecorganic.mikhael.life
By Biologist, Ecologist, PhD., Prof. Mikel de Elguezabal Méndez-Rodulfo.
73492846a, @bioecorganic (Facebook, Instagram, Blogger)
LEA Foundation & Civil Assoc., Navarre, NEA EuroRegion.
Index
1. The #EasyHealthyCellsProject overview.
2. Introduction: Our Hypotheses How Emerged Life in Paleo World The Cell, a Brief History of Life
3. From Medicine Persons and Herbalists to Physicians and Biologists
4. Non-Organic new neighbors of precious cells: pesticides, electromagnetic, heavy metals, e.g.
5. Oxidative Stress, O.S. Pollution as main OS enhancer Types of stresses and OS
6. Modern spread illness, Occurrence of OS in all tissues of each organ and system
7. List of Diseases, Illnesses, and disorders, possibly linked to OS: (chapters) = individual papers for journals!
Brain and Nervous System; Child Development, Pediatric issues Psychiatric & Psychological patterns, conditions, types; Eyes; Skin; Buccal Apparatus; Heart and Circulatory System; Bones; Muscles Glands; Kidneys; Liver; Digestive System; Lungs and Respiratory System; Auditive System.
8. Popular Knowledge related to OS: fatigue, pain, cellulitis, inflammation, liquid retention...
9. How to avoid OS: BioEcOrganic diets & supplementary nutrients, vitamins, minerals. How to cope with OS: Antioxidants, endogenous and exogenous.
10. Biotherapies, the proposed investigation to fund with ECOLABEL @BioEcOrganic. Extra Positive Behavior: better oxygenation and hydration of body cells.
1.
The #EasyHealthyCellsProject overview.
Welcome everyone, have a great day and life.
Today begins a new stage in my life story, entering the public arena, no longer so shy at a keyboard.
I do it because of the nature of my heart since childhood and an obsession with doing the right thing that comes to my mind.
Now I intend to record a series of short videos to draw the attention of families and people on planet Earth, with content that I consider true, as Popper says you must doubt and confront it, but it is my truth, trust me.
It is about the subject of cellular health, that is, the health of living beings, with emphasis in human beings, each and every one, of the souls inhabiting these suits of flesh and blood.
No longer Desmond Morris's naked monkeys, nor the Leakey couple's Eve.
It is true that my LEA Foundation has 3 enormous, unfathomable projects, but I am stubborn and a dreamer, and I will never stop trying: @eguraproject, water and energy from the sea and the sun; @congressliberty, education in Natural Freedom to undertake and grow each person or family, and, @bioecorganic, the issue that pushes us to make these videos with a certain message of hope to prevent common diseases today.
At the end of this 1st video I will try to explain what we understand by BIO ECO ORGANIC in our daily life, diet, modern lifestyles.
First, I want to point out that all the information that I speak about, say, propose, comes from reliable, scientific, morally and medically verified sources by several, some, not all, members of the various scientific communities: doctors, biologists, ecologists, chemists, physical.
There must always be discussion, there is nothing exhaustive in scientific knowledge, falsifiability is one of the primary precepts, doubt, the continuous improvement of knowledge and its understanding, is unstoppable like the evolution of species or human culture and its institutions.
Popperian positivism, embodied in the motto of the Royal Society of London: 'nullius in verba', there is no final word. We are not magicians or historicist predigitators like some arrogant character from the 19th century, who already knew the future of history through his infallible xyz method.
No, that, thinking about being the owner of the truth, is the fatal conceit, arrogant, that leads us to the path of totalitarian serfdoom.
The scientific mind, and people with access to affordable scientific knowledge, disseminated with pedagogy, is what will be attempted here. Your mind must be aware that everything said today may be less true tomorrow.
Our hypothesis at Bio Eco Organic and Easy Healthy Cells Project is to rescue a scientific framework from the 50s: Oxidative Stress.
The concept of oxidative stress in human cells was first introduced by scientist and physician Denham Harman in the 1950s. Harman proposed the "free radical theory of aging," which postulated that aging and many (almost all of which are our hypothesis) diseases associated with it could be a result of the cumulative damage caused by free radicals and oxidative stress in the body (cells).
Since then, several scientists have contributed significantly to the study of oxidative stress and its effects on human cells.
Some of these scientists include Irwin Fridovich, who discovered the enzyme superoxide dismutase in 1969; Joe McCord, who worked alongside Fridovich in researching superoxide dismutase and its role in intracellular defense against free radicals; and Lester Packer, known for his research on antioxidants and their role in cellular protection against oxidative stress.
These pioneers laid the foundation for understanding how oxidative stress can affect human cells and how antioxidant systems and free radicals are involved in physiological and pathological processes in the human body.
Free radicals are chemical structures : atoms or ions or molecules with an unpaired electron, which makes them highly reactive in the cytoplasm of each of the hundreds of millions of cells in our body, some as crucial as neurons or heart cells.
These reactive species can arise from various causes, such as different electromagnetic radiation, different sources of environmental pollution (air, water, soil, food), mental stress (excess cortisol and adrenaline?), and chemical stress. : saline, oxygenic, etc.; physical stress; thermal, light, destruction of biological tissues due to trauma, burns, accidents, or cochlear damage induced by high sound levels; poor diet.
The main types are reactive oxygen free radicals, such as superoxide, hydrogen peroxide and hydroxyl radicals, and reactive nitrogen free radicals.
These free radicals can have detrimental effects on the human body by damaging or destroying entire cells (and cascading with neighboring cells), membrane lipids and proteins, and even nuclear or mitochondrial DNA, which can contribute to aging, chronic diseases. such as cancer, heart disease, diabetes and neurodegenerative disorders, triggering autoimmune disorders....
Oxidative stress, caused by an excess presence of free radicals and a decrease in the ability of the body's cells to neutralize them (which cannot cope with the chronic -daily- levels of environmental pollutants), is caused by the cytochemical effects harmful effects of these free radicals or reactive species of Oxygen and Nitrogen.
Prevention involves leading a healthy lifestyle with a diet rich in antioxidants, which help neutralize free radicals, to reduce exposure to environmental toxins and, at the same time, increase the intake of Bio Eco Organic products.
The damage caused by free radicals can result in cell lysis, which is the rupture or destruction of the cell membrane, releasing its toxic contents to the surrounding environment, that is, neighboring cells of the same tissue or an adjacent tissue...which develops in a cascade or chain reaction effect, where there is necrotic biological material, it is an accumulation of toxins located in the body. This is what happens in endometriosis, where these toxic biological remains 'poison' the eggs that could be fertile each month, as they pass through those places where 'bio waste' accumulates that cannot leave the body for morphological-anatomical reasons.
In relation to cancer, it has always been associated with oxidative stress and tissue and cellular damage caused by free radicals with the mutation of nuclear DNA that can trigger the formation of cancer cells, tumors, masses of dead cells, destroyed by lysis of the membranes ('exploded'!) and the toxins spread directly to the neighboring cell (endocytosis/exocytosis; intra and intercellular signaling, paracrine, autocrine; ), or via the blood or lymphatic route (endocrine), 3 different routes transport of toxins to different tissues and organs.
Our hypothesis in the book chapters and in the associated research (metadata review and ecotoxicology experiments and theoretical informatic models) that we propose to the medical and scientific community is that perhaps there are no cancer genes (rather biomarkers that associate its appearance after the fact), but rather that there may be more or fewer copies [Concentration] of genes (in each type of tissue, there are dozens very different in all humans and mammals species) with the information to encode endogenous antioxidants, such as Super Oxydase Dismutases enzymes.
Thus, if there are genetic factors in the incidence of cancer and other diseases associated with oxidative stress generated by the uncontrollable increase in reactive free radicals, which are caused by various types of stress: environmental chemical (food, water, air, textiles), thermal , saline, oxygenic... and all together! Plus electromagnetic...
Superoxide dismutases are enzymes found in human cells that play a crucial role in antioxidant defense. They work to neutralize harmful free radicals, specifically the superoxide radical, which can cause oxidative damage to cells. There are three main types of Superoxide dismutases in humans (and almost all living organism or Earth!):
Copper-zinc superoxide dismutase: This enzyme is found in the cytoplasm, nucleus, and peroxisomes of cells. It contains copper and zinc ions and participates in the neutralization of superoxide radicals.
Manganese superoxide dismutase: This form of Superoxide dismutase is found in the mitochondria, where it helps protect against oxidative damage by converting superoxide radicals into oxygen and hydrogen peroxide.
Extracellular superoxide dismutase: This type of Superoxide dismutases is present in extracellular spaces, such as the spaces between cells. Eliminates superoxide radicals outside of cells, contributing to the general antioxidant defense of tissues.
These Superoxide dismutases enzymes are part of the body's natural antioxidant defense system and work together with other antioxidants such as catalase, glutathione peroxidase, and various non-enzymatic antioxidants to maintain cellular health and protect us against oxidative stress.
To maintain human health, it is essential to maintain a balance between the production of free radicals and the body's antioxidant mechanisms, through a balanced diet, regular exercise and reducing exposure to harmful environmental factors.
During the next videos, I hope to draw the attention of my Homo sapiens sisters and brothers, of families and individuals in their inalienable natural freedom, on the topics that deserve a new approach and perpetual repetition, otherwise we forget, cellular health, your health and that of your loved ones.
It's easy, bio eco organic is to eat the majority of daily foods without contaminants, and increase the intake of antioxidants daily or in supplements, and if they are of bio eco organic origin, the better!
Drink good water, breathe good air, wear safe textiles, use less salt, less sugar, less tobacco, less alcohol, less drugs, do more exercise...all this reduces chances of developing an excess of oxidative stress!
See you, and remember that all this we do is to try to achieve the Easy Healthy Cells Project research and its BioTherapy in centers for children with cancer... for this you can spread these contents and the call to use the EcoLabel system of Bio Eco Organic!! so that thousands of agribusinesses, from farms, food industries, restaurants, cafes, can use our EcoLabel easily and economically while obtaining certificates from government entities, so expensive, bureaucratic and slow!
With this Eco Label you are putting your personal and family Reputation first, showing your face, offering some, several, or almost all the products of your agribusiness with bio eco organic origin, without pesticides or assuming that you do not currently use toxic, poisonous products, for the environment, for human health and that they are healthy and safe, natural and nutritious always.
2.
Our Hypotheses How Life Emerged in Paleo World The Cell, a Brief History of Life
The emergence of life on Earth is fascinating. The history of life began around 3.8 billion years ago in what is known as the paleo world. Life emerged in a primitive and hostile environment, where conditions were very different from today.
The first life forms are believed to have been simple single-celled organisms, possibly similar to modern bacteria or archaea. These organisms evolved in an environment that lacked oxygen and relied on different biochemical processes than those we see today. The leading theory on the origin of life is the RNA world hypothesis, which suggests that self-replicating RNA molecules could have been the precursors of today's life forms.
Over time, these primitive cells evolved and diversified, giving rise to more complex forms of life. Lynn Margulis' endosymbiotic theory explains how eukaryotic cells (cells with a defined nucleus) could have arisen through symbiosis between different types of prokaryotic cells.
The study of fossils and comparative genetics have given us invaluable information about the evolution of cells and life on Earth. As conditions on the planet changed, life also adapted and evolved to survive.
The history of life in the paleo world is incredibly interesting and remains an active field of research for scientists!
Those far far 'cousins', the first bacteria and first protists, all this happens in the oceans, had the superoxide dismutases enzymes codifitcation genes ! Yes, oxidative stress is a common thing for all living organism, 100% of aerobic ones, and many of the anaerobic too.
Plants, fungi, animal, protist, bacteria, all single-celled or multi cellular organisms could suffer the destruction of cell membranes or DNA caused by free radicals, the reactive species mentioned in the first video of this serie.
As one of my favourite books when I studied biology, 'Biochemical Adaptation: Mechanism and Process in Physiological Evolution' by Hochachka, says that all aerobic organisms share the same cellular endogenous artillery to try to cope against free radicales damage, the so called Oxidative Stress.
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From Medicine Persons and Herbalists to Physicians and Biologists.
The transition from traditional medicine practitioners like medicine persons and herbalists to modern-day physicians and biologists is a fascinating evolution in the field of medicine.
Medicine persons and herbalists were often revered members of communities who relied on accumulated knowledge, passed down through generations, to treat various ailments using herbs, natural remedies, rituals, and spiritual practices. Their understanding of the body and illnesses was intertwined with cultural beliefs and often lacked empirical scientific validation.
With the advent of scientific inquiry and advancements in biology, medicine underwent a significant transformation. The shift from traditional healing to a more evidence-based approach began as scientific methods were applied to understand the human body's functioning and the causes of diseases.
Physicians today, armed with rigorous scientific training and access to cutting-edge medical technology, diagnose and treat diseases based on empirical evidence and clinical studies. They rely on a deep understanding of human biology, pharmacology, and advanced medical techniques to provide effective care.
Biologists, on the other hand, play a critical role in understanding the underlying mechanisms of diseases, conducting research, and developing new treatments. Their work spans various fields, including molecular biology, genetics, physiology, and pharmacology, contributing to the ever-expanding knowledge base of medicine.
While the methodologies and tools have changed, there's recognition and respect for the wisdom and historical contributions of traditional healers. Some modern medical practices even integrate elements of traditional medicine, acknowledging its potential benefits.
The transition from medicine persons and herbalists to physicians and biologists represents the progression of medicine from a primarily intuitive and experience-based practice to a discipline deeply rooted in scientific understanding and evidence-based methodologies. Both approaches have their merits, and the integration of traditional wisdom with modern medical practices can offer a more holistic approach to healthcare.
The transition from traditional medicine practices, such as those of Medicine Persons and Herbalists, to the more modern fields of Physicians and Biologists reflects a significant evolution in the approach to healthcare and understanding of the human body. This transition has been marked by changes in methodology, knowledge, and the overall conceptualization of health and illness. Here's a brief overview of the progression:
Traditional Medicine (Medicine Persons and Herbalists):
Holistic Approach:
Medicine Persons and Herbalists often approached health holistically, considering the interconnectedness of the body, mind, and spirit.
Remedies are often derived from natural sources, such as herbs and plants, based on traditional knowledge passed down through generations.
Spiritual and Cultural Context:
Healing practices were often intertwined with spiritual and cultural beliefs.
Rituals and ceremonies were common elements in the healing process.
Observational Learning:
Knowledge is primarily acquired through observation, experience, and oral traditions.
Transition to Physicians:
Scientific Revolution:
The emergence of the scientific revolution in the 17th century played a crucial role in shifting the focus from mystical or spiritual explanations to empirical observations and experiments.
Formal Education:
Physicians underwent formal education, often in medical schools, where they learned about anatomy, physiology, and disease pathology.
Evidence-Based Medicine:
The practice of medicine became increasingly evidence-based, relying on scientific research and clinical trials.
Technological Advances:
The development of medical technologies, such as microscopy and later diagnostic imaging, enhanced the ability to study the human body in detail.
Transition to Biologists:
Specialization:
The field of medicine continued to evolve, leading to increased specialization. Biologists focused on understanding the biological processes at the cellular and molecular levels.
Genetic Revolution:
Advances in genetics and molecular biology provided a deeper understanding of the genetic basis of diseases.
Interdisciplinary Approaches:
Biologists often collaborate with professionals from various fields, including medicine, chemistry, and physics, to address complex health challenges.
Emergence of Pharmacology:
Biologists contribute to the development of pharmaceuticals and the understanding of drug interactions at the molecular level.
Integration:
Holistic Medicine in Modern Context:
There is a growing recognition of the importance of holistic approaches in modern medicine, acknowledging the interconnectedness of physical, mental, and social well-being.
Evidence-Based Complementary Medicine:
Some traditional practices, particularly those with proven efficacy, are integrated into evidence-based complementary medicine.
Patient-Centered Care:
The shift towards patient-centered care emphasizes the importance of considering individual preferences and values in treatment plans.
The transition from traditional medicine to modern medicine and biology has been a dynamic and ongoing process, with each era contributing valuable insights to the overall understanding and practice of healthcare. While modern medicine has brought about tremendous advancements, there is also a growing appreciation for the holistic and culturally sensitive aspects of traditional healing practices. Integrating the strengths of both approaches can lead to more comprehensive and personalized healthcare strategies.
Non-Organic new neighbors of precious cells: pesticides, electromagnetic, heavy metals, e.g.
Absolutely, the environment surrounding our cells can contain various non-organic elements that might impact cellular health. Here's a breakdown of the potential effects of some of these elements:
Pesticides:
Impact on Cells: Pesticides, while intended to eliminate pests, can inadvertently affect human health. Exposure to pesticides has been linked to cellular damage, oxidative stress, and disruption of cellular functions.
Health Effects: Some pesticides are known to interfere with the endocrine system, affecting hormone balance. Long-term exposure may increase the risk of certain cancers, neurological issues, and reproductive problems.
Electromagnetic Fields:
Cellular Interaction: Electromagnetic Fields, emitted from various sources such as electronic devices, power lines, and wireless networks, can interact negatively within cells and tissues.
Potential Impact: While research on the effects of Electromagnetic Fields is ongoing, some studies suggest that prolonged exposure might contribute to oxidative stress, DNA damage, and alterations in cellular signaling.
Heavy Metals:
Cellular Toxicity: Heavy metals like lead, mercury, cadmium, and arsenic can accumulate in the body over time, leading to cellular toxicity.
Health Risks: These metals can interfere with cellular functions, disrupt enzymatic reactions, and cause oxidative stress. Chronic exposure can lead to serious fatal health issues affecting various organs.
Protection and Mitigation:
Reducing Exposure: Minimizing exposure to these non-organic elements is crucial. This might involve using protective gear when handling pesticides, limiting electromagnetic exposure by maintaining distance from devices, and avoiding areas or food and water with high heavy metal concentrations.
Balanced Lifestyle: Supporting cellular health through a balanced diet rich in antioxidants, regular exercise, and adequate sleep can bolster the body's resilience against environmental stressors.
Understanding the potential impact of these non-organic elements on cellular health is critical. Efforts to minimize exposure and promote overall wellness can significantly contribute to maintaining the integrity and functionality of our precious cells.
The factors already mentioned like pesticides, electromagnetic fields, and heavy metals, can potentially impact and harm our uniques cells and overall health.
*In our proposed investigation we want to use our biological vertebrate model (fish fry, eggs, embryos, juveniles) exposed to different wavelenght/frequencies fields from urban modern sources : wifi, bluetooth, radio, cellphones, tv, satellite, electric grids, Xrays, gamma rays, or nuclear/atomic radiativity, e.g., alone and combined, also exposing the fishes models to chemical pollutants alone, mixed and together with the EMF's of the former list.
Frequencies and wavelengths of bands of E.M. Spectrum
|
Name |
Wavelength |
Frequency (Hz) |
Photon Energy (eV) |
|
Gamma ray |
Less than 0.01 nm |
More than 10 EHz |
100 kev – 300+ GeV |
|
X – ray |
0.01 – 10 nm |
30 EHz – 30 PHz |
120 eV – 120 keV |
|
Ultraviolet |
10 nm – 400 nm |
30 PHz -790 THz |
3 eV – 124 eV |
|
Visible |
390 nm – 750 nm |
790 THz – 405 THz |
1.7 eV – 3.3 eV |
|
Infrared |
750 nm – 1 mm |
405 THz – 300 GHz |
1.24 meV – 1.7 eV |
|
Microwave |
1 mm -1 meter |
300 GHz – 300 MHz |
1.24 µ eV – 1.24 meV |
|
Radio |
1 mm – km |
300 GHz – 3 Hz |
12.4 feV – 1.24 meV |
WiFi and Bluetooth:
Wavelengths: In the 2.4 GHz and 5 GHz bands.
Frequencies: WiFi operates at frequencies around 2.4 GHz and 5 GHz.
Radio:
Wavelengths: Varies from hundreds of meters (AM radio) to meters (FM radio).
Frequencies: AM radio typically ranges from 530 kHz to 1710 kHz, while FM radio operates in the MHz range.
Cellphones:
Wavelengths: Ranges from about 30 cm to a few centimeters.
Frequencies: Cellphones operate in various frequency bands, including 700 MHz, 850 MHz, 1.8 GHz, and 2.4 GHz, depending on the technology and region.
TV:
Wavelengths: Varies from meters (VHF) to decimeters (UHF).
Frequencies: TV broadcasts cover a range from about 54 MHz (VHF low band) to 698 MHz (UHF band).
Satellite:
Wavelengths: Varies depending on the type of satellite communication (e.g., satellite TV, satellite internet).
Frequencies: Typically in the GHz range.
Low-Frequency Bands (LF): Wavelength: Greater than 1 km, Frequency: Up to 300 kHz.
Medium-Frequency Bands (MF): Wavelength: 1 km to 100 m, Frequency: 300 kHz to 3 MHz
High-Frequency Bands (HF): Wavelength: 100 m to 10 m, Frequency: 3 MHz to 30 MHz
Very High-Frequency Bands (VHF): Wavelength: 10 m to 1 m, frequency: 30 MHz to 300 MHz
Ultra High-Frequency Bands (UHF): Wavelength: 1 m to 10 cm, Frequency: 300 MHz to 3 GHz
Super High-Frequency Bands (SHF): Wavelength: 10 cm to 1 cm, Frequency: 3 GHz to 30 GHz
Extremely High-Frequency Bands (EHF): Wavelength: 1 cm to 1 mm, Frequency: 30 GHz to 300 Ghz
Satellites in the troposphere primarily operate in the UHF, SHF, and EHF bands.
Electric Grids: Wavelengths: Power line frequencies are typically 50 Hz or 60 Hz. Frequencies: 50 Hz in many parts of the world and 60 Hz in others. The associated electromagnetic fields generated by power lines are considered extremely low-frequency (ELF) electromagnetic fields.
X-rays: Wavelengths ranges from 0.01 to 10 nanometer. Frequencies: In the exahertz (EHz) range.
Gamma Rays: Wavelengths Ranges from femtometers to picometers, less than 0.01 nanometers. Frequencies: In the zettahertz (ZHz) range.
Nuclear/Atomic Radiactivity: Involves various types of radiation, including alpha, beta, and gamma radiation, each with different energy levels.
Alpha Radiation: Frequency: About 10^18 Hz (1 exahertz)
Wavelength: Approximately 10^-10 meters (0.1 nanometers)
Energy: Around 4 to 8 MeV (million electronvolts)
Beta Radiation: Frequency: Varies depending on whether it's beta-minus or beta-plus decay. For beta-minus decay, it's around 10^20 Hz (100 petahertz), and for beta-plus decay, it's in the same range.
Wavelength: Approximately 10^-11 meters (0.01 nanometers) for beta-minus decay. Energy: Beta-minus decay typically has energies ranging from a few keV (thousand electronvolts) to a few MeV.
Gamma Radiation: Frequency: Greater than 10^19 Hz (10 exahertz)
Wavelength: Less than 10^-11 meters (0.01 nanometers), Energy: Typically above 100 keV (kilo-electronvolts), extending into the MeV range.
Health Effects:
Controversy surrounds the potential health effects of prolonged exposure to Electromagnetic Fields, with some studies suggesting associations with conditions like cancer and electromagnetic hypersensitivity.
Prevention and Mitigation:
Limiting exposure by maintaining a safe distance from electronic devices.
Using devices that emit lower levels of EMFs and following safety guidelines.
3. Heavy Metals:
Impact on Cells:
Heavy metals such as lead, mercury, and cadmium can accumulate in the body and interfere with cellular function.
These metals may cause oxidative stress, damage DNA, and disrupt cellular processes.
Health Effects:
Chronic exposure to heavy metals is associated with various health issues, including neurological damage, kidney damage, and developmental problems.
Some heavy metals are known carcinogens.
Prevention and Mitigation:
Reducing exposure by avoiding contaminated water, food, and products.
Regular testing for heavy metal levels in environments and individuals.
Overall Considerations:
Regulatory Measures:
Governments and regulatory bodies play a role in setting standards and regulations to limit exposure to these non-organic factors.
Individual Choices:
Individuals can take steps to minimize exposure by being informed about potential risks and making choices that support health and well-being.
Research and Awareness:
Ongoing research is essential to better understand the long-term effects of these non-organic elements on cellular health.
It's important to note that the impact of these factors can vary based on the level and duration of exposure. Additionally, the scientific understanding of these issues is evolving, and researchers continue to investigate the potential health implications of exposure to pesticides, electromagnetic fields, and heavy metals
5. Oxidative Stress. Pollution as main OS enhancer Types of cell stresses and OS. Aerobic stress, saline stress, thermal stress, metabolic stress, hydric stress. Production of Reactive Species of Oxygen and Nitrogen. Main free radical chemical species destroying DNA, membranes and organelles in human cells. Reference bibliography.
Oxidative stress occurs when there's an imbalance between the production of reactive oxygen and nitrogen species and the body's ability to neutralize them. Environmental factors, lifestyle choices, and various stresses contribute to increased reactive oxygen and nitrogen species production, leading to cell damage. Here's an overview of different stress types, reactive species, and their impact on cells, along with some references for further reading:
Types of Cell Stresses:
Aerobic Stress:
Oxygen is essential for life, but its utilization in cells can lead to ROS production, causing oxidative damage.
Aerobic stress occurs due to excessive oxygen consumption, particularly during high metabolic activity.
Saline Stress:
High salt concentrations can induce cellular stress, affecting osmotic balance and cellular function.
It can trigger oxidative stress through various pathways.
Thermal Stress:
Extreme temperatures can disrupt cellular structures and metabolic processes, leading to oxidative damage.
Heat stress, in particular, can increase reactive oxygen species production and affect cell survival.
Metabolic Stress:
Imbalances in metabolic pathways, such as glucose metabolism or lipid metabolism, can generate reactive oxygen and nitrogen species as byproducts.
Conditions like diabetes or obesity can induce metabolic stress and contribute to oxidative damage.
Hydric Stress:
Fluctuations in water availability or extreme dehydration can stress cells, impacting cellular functions and potentially increasing reactive oxygen and nitrogen species production.
Reactive Oxygen and Nitrogen Species:
Reactive Oxygen Species:
Examples include superoxide anion (O2•−), hydroxyl radical (•OH), and hydrogen peroxide (H2O2).
reactive oxygen species are produced during normal cellular metabolism but can become harmful when their levels exceed the body's antioxidant defenses.
Reactive Nitrogen Species:
Nitric oxide (•NO) and peroxynitrite (ONOO−) are prominent reactive nitrogen species .
reactive nitrogen species can arise from reactions involving nitric oxide and superoxide, contributing to cellular damage.
Damage to Cells:
DNA Damage:
reactive oxygen and nitrogen species can cause mutations in DNA, leading to genomic instability and potential cell dysfunction or cancer.
Chemical species like hydroxyl radicals can directly damage DNA strands.
Membrane and Organelle Damage:
Lipid peroxidation caused by ROS can damage cell membranes.
Mitochondria, crucial for energy production, are vulnerable to oxidative damage, affecting cellular respiration and leading to cell dysfunction.
Oxidative Stress and its Enhancers:
1. Definition of Oxidative Stress:
Oxidative stress is a condition characterized by an imbalance between the production of reactive oxygen species and the ability of cells to detoxify or repair the resulting damage.
2. Oxidative Stress Enhancers:
Environmental Pollutants: Air pollution, heavy metals, and other environmental toxins can enhance oxidative stress.
Lifestyle Factors: Smoking, excessive alcohol consumption, and poor diet contribute to oxidative stress.
Radiation: UV radiation and ionizing radiation are sources of oxidative stress.
Inflammation: Chronic inflammation can lead to increased reactive oxygen and nitrogen species production.
Types of Cell Stresses and Oxidative Stress:
1. Aerobic Stress:
Description: Oxygen is essential for life, but its utilization can generate reactive oxygen and nitrogen species .
Example: Mitochondrial respiration produces reactive oxygen species as byproducts.
2. Saline Stress:
Description: Exposure to high salt concentrations can induce oxidative stress.
Example: Cells exposed to hypertonic environments may experience oxidative damage.
3. Thermal Stress:
Description: Fluctuations in temperature can affect cellular redox balance.
Example: Heat stress can increase reactive oxygen species production.
4. Metabolic Stress:
Description: Imbalances in metabolic pathways can lead to reactive oxygen species generation.
Example: Dysregulation of glucose metabolism in diabetes contributes to oxidative stress.
5. Hydric Stress:
Description: Changes in water availability can impact cellular redox status.
Example: Dehydration may induce oxidative stress, via the Production of Reactive Species:
1. Reactive Oxygen Species:
Examples: Superoxide, hydrogen peroxide, hydroxyl radical.
2. Reactive Nitrogen Species:
Examples: Nitric oxide, peroxynitrite.
Main Free Radical Species Impacting Cells and its deletering effects:
DNA Damage:
Free Radicals like Hydroxyl...
Breaks DNA strands, with base modifications.
Membrane Damage:
Free Radicals like Lipid peroxyl, cause Lipid peroxidation, thus cell membrane disruption, and cells malfunction, deformation, creating toxic waste affecting the cells of any given biological tissue...
Organelle Damage:
Free Radicals: Reactive Oxygen and Nitrogen Species.
Cause Mitochondrial dysfunction, Golgi apparatus or endoplasmic reticulum stress, destruction, malfunction...
Now, Examinate yourself dear friend, the role of antioxidants in counteracting oxidative stress.
6. List of modern spread illness, occurrence of oxidative stress in cells of all tissues of each organ and system of human body.
The relationship between modern spread illnesses and oxidative stress in various organs and systems of the human body is a complex area of study. Here's a general list of some modern widespread illnesses and their association with oxidative stress across different tissues and organs:
Modern Spread Illnesses like Cardiovascular Diseases:
Oxidative Stress Involvement. Oxidative Stress contributes to endothelial dysfunction, atherosclerosis, and myocardial damage. Causing damage on myocytes at Heart tissues, and blood vessels around all regions of our sacred body...
Also, the Neurodegenerative Diseases like terrible Alzheimer's, Parkinson's disseases. Here the Oxidative Stress is deeply Involved, it is implicated in neuronal (brain or nerves cells!) damage and neuroinflammation. The Tissues and organs Affected are our Brain tissues, its neurons, motor nerves, spinal cord, enteric nervous system.
Metabolic Syndrome and Diabetes:
Oxidative Stress plays a key role in insulin resistance and pancreatic beta cell dysfunction. Tissues Affected, cells, at our Pancreas and adipose tissues.
Respiratory Diseases like Asthma, Chronic Obstructive Pulmonary Disease, cancer, have close correlation with Oxidative Stress, that contributes to airway inflammation and tissue damage, destruction or cellular lysis.
This damage is now Affecting Tissues of our Lungs, pharynx, larynx, trachea, bronchial tree formed by alveoli, bronchioles, and bronchi. All these respiratory 'system' parts are made of cells, not plastic or articial polymeres dear friends ! Connective, cartilaginous tissues among other, all innerved by neurons, irrigated by blood vessels and the 'liquid' tissue ! Our precious blood !
This is so important, because, if respiratory system fails, the oxygen concentration would go down, in all our body organs and cells, causing more potential oxidative stress induced by hypoxia or even anoxia...
Cancer:
Oxidative Stress Involvement is linked to DNA damage and mutations, contributing to carcinogenesis. The Tissues Affected of any human organ would determinate the type of cancer.
For example, the Liver ! Please diminish the sugar and alcohol exagerated consuption.
Liver Diseases like Non-Alcoholic Fatty Liver Disease, or Cirrhosis, are caused by Oxidative Stress that would contributes to hepatocyte damage and inflammation, causing malfunction of this crucial organ for our body. The Tissues of Liver are degenerated, be Hepatocytes, Kupffer cells, Sinusoids, Bile ducts, and Connective tissue...
Autoimmune Diseases like Rheumatoid Arthritis, Lupus, vitiligo or Lou Gehri disease.
The Oxidative Stress Involvement is directly involved in tissue damage and immune system dysregulation. Which Tissues Affected ?: Joints, connective tissues, vessels, nerves, all around our body...
Rheumatoid Arthritis Affects our joints, causing inflammation, pain, and damage to cartilages and bones.
Systemic Lupus Erythematosus Can affect multiple organs, including the skin, joints, kidneys, heart, lungs, blood cells, and brain.
Type 1 Diabetes Targets the insulin-producing cells in the pancreas, leading to insufficient insulin production and elevated blood sugar levels.
Multiple Sclerosis Attacks the central nervous system, disrupting communication between the brain and the rest of the body.
Inflammatory Bowel Disease Includes conditions like Crohn's disease and ulcerative colitis, which affect the digestive tract.
Psoriasis, Affects the skin, causing red, scaly patches.
Vitiligo, here the immune system targets and destroys melanocytes, which are the cells responsible for producing the pigment melanin in the skin.
Hashimoto's Thyroiditis Targets the thyroid gland, leading to hypothyroidism.
Graves' Disease Affects also the thyroid gland as well, causing hyperthyroidism.
Celiac Disease Targets the small intestine in response to gluten consumption (maybe associated to pollution in modern agriculture system?)
Myasthenia Gravis Impacts the neuromuscular junctions, causing muscle weakness.
Pernicious Anemia Targets the stomach lining, leading to vitamin B12 deficiency.
Age-related Diseases like Aging-related decline, Macular Degeneration, cognitive issues...
The Oxidative Stress is linked to cellular senescence and tissue degeneration. (Any type of cell or any type of biological tissue and human organ). The Tissues Affected could be all across human body.
7. List of Diseases, Illnesses, and disorders, possibly linked to oxidative stress:
Brain and Nervous System
Neurodegenerative Diseases:
Alzheimer's disease
Parkinson's disease
Huntington's disease
Amyotrophic lateral sclerosis
Ischemic Conditions
Stroke
Transient ischemic attack
Neuropsychiatric Disorders:
Depression
Anxiety disorders
Schizophrenia
Epilepsy:
Multiple Sclerosis
Traumatic Brain Injury:
Neuropathic Pain
Autism Spectrum Disorders
Peripheral Neuropathy
Bipolar disorder
Depression
Anxiety disorders
Age-related cognitive decline
Neurodegenerative disorders
Cerebral palsy
Neurodevelopmental disorders
-----------------------------
Child Development, Pediatric issues Psychiatric & Psychological patterns, conditions, types
Child Development and Pediatric Issues:
Autism Spectrum Disorder
Attention Deficit Hyperactivity Disorder
Cerebral Palsy
Developmental Delay
-----------------------
Eye
Age-related macular degeneration
Cataracts
Glaucoma
Diabetic retinopathy
Retinitis pigmentosa
Dry eye syndrome
Uveitis
Keratoconus
-------------------
Skin
Aging of the Skin: Oxidative stress plays a role in the aging process of the skin, leading to wrinkles, fine lines, and loss of elasticity.
Skin Cancer. Reactive Oxidative Species can damage DNA, potentially contributing to the development of skin cancers, including melanoma, basal cell carcinoma, and squamous cell carcinoma.
Photoaging: Exposure to ultraviolet (UV) radiation from the sun induces oxidative stress, contributing to premature aging of the skin
Inflammatory Skin Conditions as psoriasis and atopic dermatitis.
Acne
Eczema or Dermatitis
Vitiligo
Rosacea
Contact Dermatitis
Hives or Urticaria
--------------------------
Buccal Apparatus
Periodontal Diseases:
Gingivitis
Periodontitis
Oral Cancer: Squamous cell carcinoma of the oral cavity
Oral Mucosal Disorders:
Lichen planus
Oral leukoplakia
Temporomandibular Joint Disorders:
Xerostomia or Dry Mouth, Reduced saliva flow can contribute to oxidative stress in the oral cavity.
Dental Caries, Oxidative stress may be involved in the progression of tooth decay.
Oral Infections, Infections caused by bacteria or fungi in the oral cavity can induce oxidative stress.
Burning Mouth Syndrome, Some studies suggest a potential link between oxidative stress and burning mouth syndrome.
---------------------------
Heart and Circulatory System
Atherosclerosis: Oxidative stress can contribute to the formation and progression of atherosclerotic plaques in blood vessels.
Coronary Artery Disease. Oxidative stress has been linked to the development of Coronary Artery Disease, a condition characterized by the narrowing of coronary arteries.
Myocardial Infarction or Heart Attack: Oxidative stress may play a role in the damage to heart muscle during a heart attack.
Heart Failure: Chronic oxidative stress is associated with the progression of heart failure, a condition where the heart's pumping ability is impaired.
Hypertension or High Blood Pressure: Oxidative stress is implicated in the endothelial dysfunction and vascular damage seen in hypertension.
Arrhythmias: Oxidative stress may contribute to abnormal electrical signaling in the heart, leading to arrhythmias.
Peripheral Artery Disease. Oxidative stress is linked to vascular damage in the peripheral arteries,
Heart Valve Diseases
Cardiomyopathy
Ischemia-Reperfusion Injury
Endothelial Dysfunction
---------------------------------
Bones
Osteoporosis: Oxidative stress is thought to contribute to the imbalance between bone formation and resorption, which is characteristic of osteoporosis.
Osteoarthritis: Although primarily a joint disorder, osteoarthritis involves the breakdown of cartilage, and oxidative stress may be implicated in this process.
Rheumatoid Arthritis: Chronic inflammation associated with rheumatoid arthritis can be linked to oxidative stress, potentially affecting bones and joints.
Paget's Disease of Bone: This condition involves abnormal bone remodeling, and oxidative stress may contribute to the dysregulation of bone turnover.
Bone fractures and healing: Oxidative stress can influence the process of bone fracture healing, impacting the balance between bone formation and resorption during the repair process.
.............
Muscles
Muscular Dystrophy: A group of genetic disorders characterized by progressive muscle weakness and degeneration. Oxidative stress has been implicated in the pathogenesis of muscular dystrophy.
Inflammatory Myopathies: Conditions such as dermatomyositis and polymyositis involve inflammation of the muscles. Oxidative stress may contribute to the damage observed in these inflammatory muscle diseases.
Amyotrophic Lateral Sclerosis is a neurodegenerative disease affecting motor neurons and muscles. Oxidative stress is considered one of the factors contributing to the progression of Amyotrophic Lateral Sclerosis .
Fibromyalgia: While the exact cause of fibromyalgia is unclear, oxidative stress has been suggested as a potential contributor to the symptoms, including muscle pain and fatigue.
Sarcopenia: Age-related loss of muscle mass and function. Oxidative stress play a key role in the development of sarcopenia.
Ischemia-Reperfusion Injury: This occurs when blood supply returns to tissues after a period of ischemia (lack of blood flow). Oxidative stress contribute to muscle damage.
Mitochondrial Myopathies: These are a group of disorders caused by dysfunctional mitochondria, leading to impaired energy production in muscles. Oxidative stress is involved in mitochondrial dysfunction.
Rhabdomyolysis: A condition involving the breakdown of muscle tissue, releasing a protein called myoglobin into the bloodstream. This can result also in kidney damage.
Chronic Fatigue Syndrome: studies suggest a potential role of oxidative stress in contributing to muscle fatigue and weakness.
Peripheral Artery Disease: Reduced blood flow to the extremities can lead to oxidative stress, impacting muscle health and function
-----------------------
Endocrine and exocrine Glands
Diabetes Mellitus: Chronic hyperglycemia in diabetes can lead to increased oxidative stress, affecting various organs including the pancreas (endocrine gland) and impairing insulin function.
Thyroid Disorders: Oxidative stress has been implicated in thyroid dysfunction and disorders such as hypothyroidism and hyperthyroidism.
Adrenal Disorders: Conditions affecting the adrenal glands, such as adrenal insufficiency or Addison's disease, involve oxidative stress.
Polycystic Ovary Syndrome is a common endocrine disorder in women of reproductive age, has been associated with oxidative stress.
Pituitary Disorders:Disorders affecting the pituitary gland, such as pituitary adenomas, may have a link to oxidative stress.
Endometriosis: Oxidative stress has been suggested as a factor in the development and progression of endometriosis, a disorder affecting the endometrial tissue.
Neuroendocrine Tumors: Tumors arising from neuroendocrine cells, such as carcinoid tumors, involve oxidative stress.
Cystic Fibrosis:This genetic disorder affects exocrine glands, linked to increased oxidative stress and inflammation.
Chronic Pancreatitis:Oxidative stress plays a role in the inflammation and damage to the pancreas seen in chronic pancreatitis.
Sjögren's Syndrome: An autoimmune disorder that primarily affects exocrine glands, leading to dry eyes and dry mouth. Oxidative stress may contribute to the pathology.
Hashimoto's Thyroiditis: An autoimmune condition affecting the thyroid gland, oxidative stress may play a role in the inflammation and destruction of thyroid tissue.
Gastrointestinal Disorders:
- Diseases affecting exocrine glands in the digestive system, such as chronic pancreatitis or inflammatory bowel diseases, may involve oxidative stress.
Kidney
Chronic Kidney Disease: Oxidative stress is implicated in the progression of Chronic Kidney Disease It can contribute to inflammation, fibrosis, and damage to renal cells.
Acute Kidney Injury: Oxidative stress is recognized as a factor in the development of Acute Kidney Injury, especially in cases involving ischemia-reperfusion injury and inflammation.
Diabetic Nephropathy: Diabetes is associated with increased oxidative stress, and diabetic nephropathy, a complication of diabetes affecting the kidneys, involves oxidative damage to renal tissue.
Hypertensive Nephropathy: Hypertension can lead to oxidative stress, and chronic exposure may contribute to renal damage and the development of hypertensive nephropathy.
Polycystic Kidney Disease: Oxidative stress has been suggested to play a role in the progression of Polycystic Kidney Disease, contributing to cyst formation and kidney damage.
Glomerulonephritis: Inflammation associated with glomerulonephritis can be linked to increased oxidative stress, contributing to kidney injury.
Nephrolithiasis or Kidney Stones: Oxidative stress has been linked to the formation of kidney stones, and it may contribute to the damage of renal tissue during stone formation.
Renal Ischemia-Reperfusion Injury: During procedures like kidney transplantation or certain surgeries, oxidative stress may occur due to the restoration of blood flow, leading to injury to renal tissue.
Drug-Induced Nephrotoxicity: Some drugs may induce oxidative stress in the kidneys, causing nephrotoxicity. Examples include certain antibiotics, non-steroidal anti-inflammatory drugs, and chemotherapeutic agents.
Aging-Related Kidney Changes
-------------------------------
Liver
Non-Alcoholic Fatty Liver Disease: Oxidative stress plays a role here, a condition characterized by the accumulation of fat in the liver.
Alcoholic Liver Disease: Chronic alcohol consumption can lead to oxidative stress in the liver, contributing to the development and progression of alcoholic liver disease.
Hepatitis: Both viral hepatitis (such as hepatitis B and C) and autoimmune hepatitis can induce oxidative stress in the liver.
Cirrhosis: Prolonged oxidative stress can contribute to the development of liver cirrhosis.
Liver Fibrosis: Oxidative stress is implicated in the fibrotic processes that lead to scarring of the liver tissue.
Hemochromatosis: Excess iron accumulation in the liver, as seen in hemochromatosis, can be linked to oxidative stress and damage.
Wilson's Disease: This genetic disorder leads to copper accumulation in various organs, including the liver, and oxidative stress is thought to contribute to the pathology.
Primary Biliary Cholangitis: This is an autoimmune disease that affects the bile ducts in the liver, and oxidative stress has been implicated in its pathogenesis.
Non-Alcoholic Steatohepatitis is a more severe form of non-Alcoholic Fatty Liver Disease, and oxidative stress is considered a key factor in the progression from simple steatosis to inflammation and liver damage.
Hepatocellular Carcinoma or Liver Cancer.
Digestive System
Inflammatory Bowel Disease
Ulcerative colitis
Crohn's disease
Irritable Bowel Syndrome: studies suggest a potential role of oxidative stress in Irritable Bowel Syndrome.
Gastroesophageal Reflux Disease, Oxidative stress may contribute to the inflammation and damage of the esophageal lining in Gastroesophageal Reflux Disease.
Peptic Ulcer Disease: Helicobacter pylori infection, which is associated with peptic ulcers, can induce oxidative stress.
Colorectal Cancer: Oxidative stress is believed to be involved in the development and progression of colorectal cancer.
Liver Diseases:
Non-alcoholic fatty liver disease
Alcoholic liver disease
Hepatitis
Cirrhosis
Pancreatitis: Oxidative stress may contribute to the inflammation of the pancreas.
Gallstone Formation: Some studies suggest a link between oxidative stress and the formation of gallstones.
Celiac Disease: Oxidative stress may play a role in the inflammation associated with celiac disease.
Gastritis: Chronic inflammation of the stomach lining, which may involve oxidative stress
------------------------
Lungs and Respiratory System
Chronic Obstructive Pulmonary Disease: A group of progressive lung diseases, including chronic bronchitis and emphysema, where oxidative stress plays a role in the inflammation and damage to lung tissues.
Asthma: Oxidative stress is involved in airway inflammation and bronchoconstriction in asthma patients.
Interstitial Lung Disease: A group of lung disorders characterized by scarring of lung tissue, where oxidative stress may contribute to inflammation and fibrosis.
Pneumonia: Oxidative stress can exacerbate lung injury during pneumonia by promoting inflammation and damage to lung cells.
Acute Respiratory Distress Syndrome: A severe lung condition often associated with inflammatory responses, where oxidative stress contribute to tissue damage.
Lung Cancer: Oxidative stress is implicated in the initiation and progression of lung cancer by promoting DNA damage and genetic mutations.
Pulmonary Fibrosis: A condition characterized by the scarring of lung tissue, where oxidative stress may contribute to the fibrotic process.
Bronchitis: Both acute and chronic bronchitis involve inflammation of the bronchial tubes, and oxidative stress can contribute to the inflammatory response.
Cystic Fibrosis: A genetic disorder that affects the lungs and digestive system, where oxidative stress plays a role in inflammation and lung damage.
Obstructive Sleep Apnea: Oxidative stress has been implicated in the inflammation and endothelial dysfunction associated with sleep apnea.
Tuberculosis: Oxidative stress is involved in the host immune response against Mycobacterium tuberculosis, and it may contribute to tissue damage in the lungs
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Auditive System
Age-related Hearing Loss or Presbycusis: Oxidative stress is believed to contribute to the gradual decline in hearing that occurs with aging.
Noise-Induced Hearing Loss: Exposure to loud noises can lead to oxidative stress in the auditory system, potentially causing damage to the hair cells in the inner ear.
Tinnitus: Oxidative stress may play a key role in the development or exacerbation of tinnitus, a condition characterized by persistent ringing or buzzing sounds in the ears.
Meniere's Disease: This disorder, which involves inner ear dysfunction, may be associated with oxidative stress.
Ototoxicity: Certain medications and chemicals can cause damage to the ear structures and induce hearing loss through oxidative stress.
Otosclerosis: A condition where abnormal bone growth in the middle ear can lead to hearing loss, and oxidative stress is involved in the pathophysiology.
Vestibular Disorders: Conditions affecting the balance system, such as vestibular neuritis or labyrinthitis, have oxidative stress as a contributing factor.
Autoimmune Inner Ear Disease: This rare immune system disorder affecting the inner ear involve oxidative stress.
Acoustic Trauma: Sudden exposure to extremely loud sounds can lead to oxidative stress and damage to the auditory system.
Genetic Hearing Loss: Some genetic disorders associated with hearing loss involve oxidative stress as part of their mechanisms.
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8. Popular Knowledge related to oxidative OS: fatigue, pain, cellulite, inflammation, liquid retention. Reference bibliography.
Oxidative stress can indeed contribute to various health issues, and there's a wealth of research exploring its impact on conditions like fatigue, pain, cellulitis, inflammation, and fluid retention.
Fatigue: Oxidative stress has been linked to fatigue in conditions like chronic fatigue syndrome or fibromyalgia. Studies often refer to the role of oxidative stress in exacerbating fatigue. One example of such studies is this : "Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms" by Spence Kennedy in 2005, published in Free Radical Biology & Medicine.
Pain: Oxidative stress contributes to pain perception and sensitivity, especially in conditions like chronic pain or neuropathic pain. Studies those carried out by Loeser, Collins and colaborators in 2016 appeared in The Journal of Clinical Investigation, discuss this relationship.
Cellulite: Oxidative stress occurs when there is an imbalance between the production of free radicals (highly reactive molecules) and the body's ability to neutralize them through antioxidants. Free radicals can damage cells, including skin cells, and contribute to various skin issues, including cellulite.
Cellulite is a condition characterized by the appearance of dimpled, lumpy skin, often on the buttocks, thighs, and hips. It is more common in women than in men and is influenced by factors such as genetics, hormonal changes, and lifestyle. While cellulite is not a health concern, it can be a cosmetic concern for some individuals.
Studies suggest that oxidative stress may play a role in the development and progression of cellulite.
Inflammation: Oxidative stress can lead to inflammation, and chronic inflammation may contribute to the formation of cellulite. Inflammation can affect the connective tissue and fat cells in the skin, potentially influencing the appearance of cellulite.
Collagen Degradation: Oxidative stress can contribute to the breakdown of collagen, a protein that provides structure and elasticity to the skin. The weakening of collagen fibers may be associated with the formation of cellulite.
Blood Flow and Toxin Accumulation: oxidative stress impact blood circulation and promote the accumulation of toxins in fat cells, contributing to the development of cellulite.
Inflammation: Oxidative Stress is intricately linked to inflammation as it can trigger inflammatory pathways. A plethora of studies, such as "Oxidative stress and inflammation in liver carcinogenesis" by Kim Suh and colaboratorsin 2018 appeared in Cancer Research and Treatment, discuss the relationship between Oxidative Stress and inflammation. The atomic or 'molecular' volume of reactive oxygen or nitrogen species have a tiny 'mass and volume', so
The atomic mass of oxygen is approximately 16 atomic mass units. The atomic mass of nitrogen is approximately 14 atomic mass units.
For specific reactive species:
Superoxide has an atomic mass of approximately 32 atomic mass units .
Hydrogen peroxide has an atomic mass of about 34 atomic mass units.
Hydroxyl radical has 17.01 atomic mass units
superoxide anion, hydrogen peroxide, hydroxyl radical, and singlet oxygen. These oxygen reactive species can exist in various states, including gas and liquid, depending on specific conditions. For instance, hydrogen peroxide is a liquid at room temperature, while superoxide anion is typically encountered as a free radical gas in biological systems. The physical state of these species can be influenced by factors such as temperature and pressure. In a biological context, ROS are often generated and function within cellular compartments or in the aqueous environment of cells, where they may exist as dissolved liquid species rather than as gases.
Both 'behavoirs' of these chemical structures 'floating' in everyone of our cells could add presure, volume and deform our precious cells, anyone of any tissue, in a ramdom gland or organ of human bodies...
Deformation of cells normal morphology, tissues, organs anatomy, could lead to malfunction or dysfunction of metabolism, physiology and contribute to overall non homeostatic performances in our daily life.
Fluid or liquids Retention: While the direct link between oxidative stress and fluid retention might not be extensively studied, oxidative stress can impact vascular health, leading to conditions that might involve fluid retention. "Oxidative stress and inflammation in the cardiovascular system" by Griendling and FitzGerald in 2003, appeared in 'Circulation'.
Inflammation: Both fluid retention and oxidative stress are often associated with inflammatory processes. Inflammatory signals can contribute to both conditions.
Endothelial Dysfunction: Oxidative stress can impair the function of endothelial cells lining blood vessels, influencing fluid exchange and potentially contributing to fluid retention.
Management: Diet: Antioxidant-rich diets may help reduce oxidative stress. Diets low in sodium and rich in potassium can be beneficial for managing fluid retention.
Lifestyle Changes: Regular physical activity can help improve fluid balance and reduce oxidative stress.
Medical Treatment: Addressing the underlying causes of fluid retention and oxidative stress is crucial. Medications may be prescribed to manage specific conditions.
9. How to avoid oxidative stress OS: Organic diets & supplementary nutrients, vitamins, minerals. How to cope with OS: Antioxidants, endogenous and exogenous. Reference bibliography.
Avoiding oxidative stress involves several strategies, primarily centered around lifestyle and dietary choices. Organic diets rich in antioxidants and essential nutrients can help prevent and mitigate oxidative stress. Here's a breakdown:
Prevention Strategies:
Organic Diet: Choose organic, whole foods rich in antioxidants like fruits, vegetables, nuts, seeds, and whole grains. These foods contain vitamins (C, E), minerals (selenium, zinc), and phytochemicals (flavonoids, polyphenols) that combat oxidative stress.
Essential Nutrients: Ensure adequate intake of essential nutrients known to combat oxidative stress, such as vitamins C and E, selenium, zinc, and coenzyme Q10. These can be obtained from both dietary sources and supplements.
Balanced Lifestyle: Incorporate regular exercise, adequate sleep, and stress management techniques like meditation or yoga. These lifestyle factors can help reduce oxidative stress.
Coping Strategies:
Antioxidants: Consume foods or supplements rich in antioxidants to counteract oxidative stress. Examples include berries, leafy greens, nuts, seeds, green tea, and supplements like alpha-lipoic acid, glutathione, or resveratrol.
Endogenous Antioxidants: Your body produces its own antioxidants, like glutathione and superoxide dismutase. Encourage their production through a balanced diet, exercise, and reducing exposure to toxins.
Exogenous Antioxidants: Consider supplementing with antioxidants if your diet lacks variety or if your body requires extra support. However, it's important not to overdo supplementation, as excessive amounts of some antioxidants can be harmful.
Avoiding Oxidative Stress:
Organic Diets:
Choose organic fruits and vegetables to reduce exposure to pesticides and herbicides, which may contribute to oxidative stress.
Nutrient-Rich Diet:
Ensure a well-balanced diet rich in antioxidants, vitamins, and minerals. Include a variety of colorful fruits and vegetables, whole grains, nuts, seeds, and lean proteins.
Hydration:
Drink plenty of water to support overall health and maintain proper cellular function.
Limit Processed Foods:
Reduce the consumption of processed foods, as they may contain unhealthy fats, additives, and preservatives that can contribute to oxidative stress.
Omega-3 Fatty Acids:
Include sources of omega-3 fatty acids, such as fatty fish (salmon, mackerel) and flaxseeds, which have anti-inflammatory properties.
Coping with Oxidative Stress:
Antioxidant-Rich Foods:
Consume foods high in antioxidants, such as berries, dark chocolate, spinach, kale, and green tea.
Supplementary Nutrients:
Consider supplements if needed, such as vitamin C, vitamin E, selenium, and zinc, which have antioxidant properties.
Herbs and Spices:
Include herbs and spices like turmeric, ginger, and cinnamon, which have antioxidant and anti-inflammatory effects.
Regular Exercise:
Engage in regular physical activity, as exercise promotes the production of endogenous antioxidants and helps combat oxidative stress.
Adequate Sleep:
Ensure sufficient and quality sleep, as sleep is crucial for the body's repair processes and antioxidant defense.
Stress Management:
Practice stress-reducing techniques such as meditation, deep breathing, and yoga, as chronic stress can contribute to oxidative stress.
10. Biotherapies, the proposed investigation to fund with ECOLABEL @BioEcOrganic. Extra Positive Behavior: better oxygenation and hydration of body cells.
Biotherapies @BioEcOrganic #BioTherapy (BEO:BT) encompass easy, robust, cheap and trusful therapeutic approaches aimed at enhancing the body's natural processes for healing and well-being. Strategies focusing on better oxygenation and hydration of cells to prevent oxidative stress (OS) can involve various practices and treatments. Here are the proposed methods and scientific references that may be relevant:
Oxygenation Techniques:
Deep Breathing Exercises: Techniques like diaphragmatic breathing or pranayama from yoga can improve oxygen intake and circulation.
Hyperbaric Oxygen Therapy: Delivers oxygen at increased pressure, promoting oxygen absorption in tissues (Reference: UHMS Hyperbaric Oxygen Therapy Indications, 14th Edition).
Exercise: Regular physical activity can improve cardiovascular health, enhancing oxygen delivery throughout the body.
Hydration Strategies:
Adequate Water Intake: Maintaining proper hydration levels by consuming water and hydrating foods.
Intravenous Hydration: In cases of severe dehydration, Intravenous Hydration therapy can rapidly replenish fluids
Nutritional Support:
Antioxidant-Rich Diet: Consuming foods high in antioxidants (vitamins C and E, beta-carotene, etc.) can help combat oxidative stress.
Supplements: Some supplements like N-acetylcysteine, glutathione, or coenzyme Q10 have shown antioxidant properties.
2.
EHCP RESEARCH
Abstract
The research line involves experimental ecotoxicology tests, mathematical modeling of hazards causing cell damages, and applied research in Children Cancer Centers using antioxidant BioTherapy.
The hypothesis is that health conditions rely on cell performances, with oxidative stress (OS) as a common response to cell failure, triggered by environmental pollution and electromagnetic fields.
The proposal aims to investigate electromagnetic fields' role in enhancing OS, configure a new mathematical model, and propose a new Biotherapy.
Introduction
Cancer research has focused on radiotherapy, chemotherapy, and immunotherapy, but an integrated translational approach can tackle cancer spreading through new societies adopting industrial lifestyles.
The team sustains that more effort should be invested in research on the causes triggering all types of cancer and in creating novel, less invasive, and more affordable therapies.
The proposal suggests a 3-phase research involving ecotoxicology essays, mathematical probabilistic models, and applying a new 'BioTherapy' designed for cancer pediatric patients.
Preliminary Data
The research recalls the classical Free Radicals theory of Harmann (1956) leading to Oxidative Stress (OS) as the source of a majority of health conditions, including cancer.
It aims to prove if OS is causing a majority of diseases, and if new therapies could bring to balance unbalanced human cells levels of free radicals.
If living in an ideal environment is not possible, society must counteract and help cellular systems with extra caring about contaminants and supplementary antioxidants.
Project Aims and Objectives
The first phase aims to understand the effects of electromagnetic fields on free radicals generation (OS) through cell membrane permeability, increasing the probabilities of cytotoxic processes.
The second phase aims to create a Mathematical Probabilistic Model for OS occurrence for every human cell type under chemical pollutants, taking in account the affinities of tissues and cell types towards physical-chemical features.
The third phase is the application of a novel 'BioTherapy' for cancer patients, designed to provide a quadruple treatment approach to boost the patients' cells health.
Transformative Approaches and Expected Results
The research should give a better understanding in each of the 3 designed Phases regarding the incidence of electromagnetic fields, algorithms, and BioTherapy.
We will obtain a direct output on the measured incidence of various sources of modern electromagnetic fields on the permeability of cells' membranes facing chemical pollutants.
The goal is to ameliorate the living standards of cancer patients and of general population also via preventive approaches and health education.
Methodology and Scientific Approach
Phase 1 involves ecotoxicological essays using a mesocosm approach with groups of fishes fries (Salmo trutta) exposed to pesticides and electromagnetic fields.
Phase 2 involves the construction of a Probabilistic Model Open Program created by algorithms and equations by a team of experts to predict the occurrence of major OS.
Phase 3 considers basic endpoints measured from cancer patients of the Pediatric Oncology Center in Cumaná city, Sucre, Venezuela, following the same BioTherapy.
Work Plan and Timeline
Phase 1 of EHCP would take a 1-year round of various Ecotoxicology essays at the University labs contracted.
Phase 2 and Phase 3 would take 3 years of continuous work in parallel, involving intellectual effort and rigorous work.
Study Limitations and Contingency Plans
For Phase 1, the main threat would be not to count with the diploid and triploid fries of Salmo trutta fario specimens, in such a case, the Zebrafish model will be used.
For Phase 2, the main threat possibly limiting this Mathematical/Probabilistic thinking could be the lack of enough metadata, requiring collaborative work of peers worldwide.
For Phase 3, a potential adverse reaction during the quadruple treatment of the BioTherapy may occur, in such case, the BioTherapy will be dropped out in that patient.
Impact
Phase 1: contributing to ecotoxicology research, defining new equations for transmembrane transport, and raising awareness about cytotoxicity enhancement.
Phase 2: constructing metadata matrices, potentially creating a predictive model for OS occurrence, and developing a scientific app for medical professionals.
Phase 3: providing an affordable BioTherapy, recalling classic antioxidant theories, and offering open-source recipes for diets, baths, and supplements.
Ethical, Social, Legal and Environmental Project Implications
The project will use fishes as vertebrate models that are only hatched for releasing in some rivers.
Also, during the BioTherapy Phase 3, the quadruple treatments will be applied to children with cancer under medical staff supervision.
Dissemination, Social Engagement and Knowledge Transfer
Besides reports, the project envisages to publish papers in accessible Scientific Journals.
There is also a priority aim to transmit all the new contents, once proved, to the entire society via internet open pages, social networks, forums, emails.
All material, videos and presentations will be able to share it with any researcher or professor or health professional willing to replicate the project's information and tools towards its own country or region in any language.
Cited References, EHCP, LEA Foundation
The section provides a list of cited references used in the proposal, including articles and publications related to cancer research, oxidative stress, and environmental factors.
ApplicationPreview
The proposal titled "Easy Healthy Cells Project" (EHCP) aims to investigate the role of electromagnetic fields on Oxidative Stress (OS) enhancement.
The project is led by Dr. Mikel De Elguezabal, biologist, from Asociación Civil Fundación Luís Elguezabal Aristizabal, LEA.
The thematic area of the project is Oncology, classified as Clinical and Translational, with keywords related to eukaryotic cells, environmental illness, and therapeutics.
Budget
The total requested budget is $498,500.00, covering personnel, travel, equipment, consumables, publications, dissemination activities, and subcontracting audits.
Personnel costs are $219,000.00, including Dr. Mikel de Elguezabal, Dr. Isabel Chávez, Dr. Gregorio Martínez, Dr. Edgard Márquez, and Dr. Elizabeth Méndez.
Equipment costs are $100,000.00, including equipment for the Pediatric Oncology Centre for Phase 3 and computers for Phase 2.
Declarations
The Host Organization is a Non-profit Research Organization.
The results of the project are not subject to rights held by for-profit organizations, and the project complies with ethical principles.
Project Team
The project leader is Mikel De Elguezabal.
The EHCP Team includes Dr. Gregorio Martínez, Dr. Edgar Márquez, Dr. Isabel Chaves Pinto, and Dr. Elizabeth Méndez Rodulfo.
EasyHealthyCellsProject
There are concerns about WiFi in schools, glyphosate usage, and air pollution relating to public health.
There is a raised concern for cell stress from food, air, and water pollution plus electromagnetic pollution.
The proposal seeks to examine stress Oxidative, pH, and performance and will test agrochemicals on test fish with different sources of electromagnetic radiation.
Resumed View of EHCP Project
The project aims to investigate the impact of environmental pollution, specifically electromagnetic fields and common pesticides, on oxidative stress (OS) in cells.
The project involves ecotoxicology tests, mathematical modeling, and biotherapy application,.
The anticipated outcomes include improved health conditions for pediatric cancer patients and wider application of the proposed biotherapy.
3. BIOTHERAPY
The BioTherapy initiative within the Easy Healthy Cells Project (EHCP) represents a pivotal phase in the global effort to provide accessible, non-invasive, and biologically grounded therapies for pediatric oncology centers worldwide. By leveraging the body's natural detoxification pathways and harnessing the power of plant-derived antioxidants, BioTherapy aims to offer a complementary approach to traditional cancer treatments.
1. Revisiting the Antioxidant Paradigm
BioTherapy draws upon the foundational theories of oxidative stress and free radicals, emphasizing the role of antioxidants in mitigating cellular damage. Oxidative stress, resulting from an imbalance between free radicals and antioxidants, has been implicated in the pathogenesis of various diseases, including cancer, autoimmune disorders, and neurodegenerative conditions citeturn0search0. Phytochemicals—bioactive compounds found in plants—exhibit potent antioxidant properties, offering protective effects against such diseases citeturn0search0.
2. Open-Source Therapeutic Protocols
A cornerstone of the BioTherapy approach is its commitment to transparency and accessibility. By publicly sharing detailed protocols for the preparation and administration of plant-based antioxidant treatments, EHCP empowers healthcare professionals worldwide to replicate and adapt these therapies within their clinical practices. This open-source model not only fosters global collaboration but also ensures that even resource-limited settings can benefit from these interventions.
3. Integrative Detoxification Techniques
Beyond dietary interventions, BioTherapy incorporates traditional detoxification methods to enhance the body's natural elimination processes. One such technique involves dermal treatments using alkaline saline baths infused with medicinal plants, aiming to stimulate lymphatic, sebaceous, and sudoriferous systems for toxin removal. Additionally, the application of Japanese bamboo leaf patches on the soles of the feet overnight is explored for its potential in facilitating detoxification through the skin.
4. Empowering Global Health Entrepreneurship
By aligning with international standards set by organizations such as the World Health Organization (WHO), Food and Agriculture Organization (FAO), Codex Alimentarius, and International Organization for Standardization (ISO), BioTherapy paves the way for local entrepreneurs to develop and distribute these therapies. This initiative not only promotes health equity but also stimulates economic growth by encouraging the production and dissemination of affordable, plant-based health solutions.
In summary, the BioTherapy phase of the EHCP embodies a holistic, inclusive, and scientifically grounded approach to health care. By revisiting and revitalizing classic antioxidant theories, promoting open-source collaboration, integrating traditional detoxification practices, and fostering global entrepreneurship, BioTherapy holds the promise of transforming pediatric oncology care and beyond.
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